During the last decade, we have seen remarkable improvements on HIV treatments. In some countries, such improvements have allowed controlling HIV infection with high efficacy and reasonably simple treatment schedules, but it has also shifted the profile of HIV patients, who now tend to be increasingly aged. Overall, it is estimated that 50% of HIV-infected subjects are over 50 years of age and the proportion of infected people older than 65 years grew 10-fold in the last years.

The increased life expectancy together with the HIV-related chronic inflammation and the long exposure to some antiretroviral drugs are the main reasons of the accelerated aging in HIV-infected patients. This scenario carries new challenges for healthcare professionals, who have now to provide health care to patients with a significant comorbidity burden and polypharmacy treatments.

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